![]() In order to accelerate the screening of all possible PBAEs, the results of a small pool of polymers (n = 90) were used to train a variety of Machine learning (ML) methods using only polymers properties available in public libraries or estimated from the chemical structure. ![]() PBAEs are copolymer of amines and di-acrylates further end-capped with other amine, therefore encompassing a very large research space for the identification of optimal candidates. We introduced poly beta amino esters (PBAEs) polymers to effectively deliver drugs into cartilage tissues. While an effective delivery system is sought, the only option is using high drug doses that can lead to systemic side effects. ![]() Despite the large prevalence of diseases affecting cartilage (with knee osteoarthritis affecting 16% of population globally), no curative treatments are available because of the limited capacity of drugs to localise in such tissues caused by the low vascularisation and electrostatic repulsion. ![]()
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